• Startdatum:
  • 31 mei 2021
  • Cursusduur:
  • 5 dagen
  • Werkzaam als:
  • PhD

Repeated measurements in clinical and epidemiological research
The course covers statistical methods to be used in the situation where one or more outcome variables are repeatedly measured in time on the same experimental unit. For instance, in a clinical trial, the outcome variable can be measured at baseline and at different times during the treatment period. For this type of data, traditional regression models cannot be used since outcomes of the same subject may be correlated, and this should be taken into account in the statistical model. Other examples of studies where there is a similar dependency in the outcome measurements are cluster randomised trials and meta-analysis. In the last one or two decades, much progress has been made in the development of new methods of analysis for dependent outcome data. In recent years several of these new methods have been implemented in commercially available computer packages. In the course, first an overview of classical approaches to repeated measurements will be given. Then modern methods are introduced. For approximately normally distributed response, focus will be on the General Linear Mixed Model. For non-normal response, the generalized estimating equations (GEE) approach for marginal models is discussed. Also some attention will be paid to random effects model, for instance random effects logistic regression. Examples of clinical and epidemiological applications will be given. In the computer labs, exercises with R and SPSS are used to get experience with applying these new methods to real data.

Course material
All study materials are supplied electronically only. The material will be covered in lectures and practical sessions. The course will be given in a blended learning style integrating online media as well as traditional face-to-face teaching using zoom online meetings.

  • During the lectures the theory will be covered and worked-out examples will be discussed. The lectures will be given mainly with online media combined with face-to-face teaching sessions where a short review of the material will be provided followed by questions and discussions on the covered topics.
  • During the practical sessions, the theory covered will be applied by analysing real datasets

Familiarity with standard regression models such as the multiple linear regression and logistic regression model. No pre-knowledge of repeated measurements analysis is required. Familiarity with data processing in R and/or SPSS. The participants may use either R or SPSS during the practicals. Solutions for both software will be provided.

Teaching environment
Daily plenary introductions by the teacher in the morning, followed by self-study video's and practical assignements, and plenary discussions at the end of the course days about the course material of that day.

Certificate of Attendance / Assignment 
A post-course exam will have to be completed in the week after the course for those who need the ECTS  (1.5).The link to the exam will be distributed on Monday 7 June. The deadline for submitting the exam results is on Friday 11 June. In general; to obtain a certificate of participation, all lectures and practical exercise sessions should be attended. 

Course material and lectures are in English.

Target group
Master and PhD students in the bio-medical sciences.

Organizing committee

  • Dr. S. Tsonaka
  MONDAY 31 MAY 2021
08:45 Log-in / registration
09:00 Opening Session
Dr. Roula Tsonaka, LUMC
10:00 Self study - lectures (videos) & practical exercises
16:00 Plenary discussion
Dr. Roula Tsonaka, LUMC
17:00 End of course day


09:00 Self study - lectures (videos) & practical exercises
16:00 Plenary discussion
Dr. Roula Tsonaka, LUMC
17:00 End of course day


  Wednesday 2 June 2021
08:45 Log-in / registration
09:00 Self study - lectures (videos) & practical exercises
16:00 Plenary discussion
Dr. Roula Tsonaka, LUMC
17:00 End of course day           


09:00 Self study - lectures (videos) & practical exercises
16:00 Plenary discussion
Dr. Roula Tsonaka, LUMC
17:00 End of course day


  FRIDAY 4 JUNE 2021
09:00 Self study - lectures (videos) & practical exercises
15:30 Plenary discussion
Dr. Roula Tsonaka, LUMC
16:30 End of course
  POST-COURSE ASSIGNMENT (via learning environment)
  Monday 4 June - Friday 11 June 2021
  POST-COURSE ASSIGNMENT (RESIT) (via learning environment)
  Monday 21 June - Friday 25 June 2021
  POST-COURSE - REVIEW RESULT ASSIGNMENTS (via learning environment)
Monday 28 June - Sunday 4 July 2021
Dr. S. Tsonaka
Regular course fee € 450,-
Reduced fee for PhD students LUMC  € 150,-
Reduced fee for employees LUMC € 150,-
BA/MA students of the Leiden University  Free of charge *
BA/MA students of other universities (non Leiden University)            € 75,- *

* Limited places available. In order to validate your student registration, you must register with your student e-mail address and submit your student number on the registration form. In addition, a scan of your student pass will have to be submitted to boerhaavenacholing@lumc.nl. Please note that a € 45,- cancellation fee will be charged to students who do not attend the course or who are too late cancelling their participation.